Interaction of human organic anion transporters
Abstract human organic anion transporter 2 (hoat2 [slc22a7]) is highly expressed in the human liveralthough localization, gene expression, substrate specificity and transport mechanisms of other human oat isoforms such as human oat1 (hoat1), human oat3 (hoat3) and human oat4 (hoat4) have been elucidated, information concerning human oat2 (hoat2) is less defined. In order to elucidate the molecular mechanisms for the pharmacokinetics of indoxyl sulfate in human, we examined the interactions of human organic anion transporters (human-oats) and human organic cation transporters (human-octs) with indoxyl sulfate using stable transfectants. Introduction of organic anion transporters (slc22a) and a regulatory mechanism by caveolins woon kyu lee1, by protein-protein interaction, such as caveolin which is compositional protein of caveolae structure this review, we will give an introduction of organic anion transporters and its regulatory mechanisms keywords:kidney, organic. Organic anion transporters (oats) are important in the renal secretion, and thus, the clearance, of many drugs and their functional change can result in pharmacokinetic variability in this study, we applied transport rates measured in vitro using oat-transfected human embryonic kidney cells to predict human renal secretory and total renal clearance of 31 diverse drugs. Organic anion transporting polypeptide 1b1 (oatp1b1) and organic anion transporting polypeptide 1b3 (oatp1b3), belonging to the slco family of proteins, are specifically expressed in the sinusoidal membranes of the liver, and are known to interact with a variety of drugs.
Integral component of plasma membrane, sodium-independent organic anion transmembrane transporter activity, sodium-independent organic anion transport. An organic-anion-transporting polypeptide (oatp) is a membrane transport protein or 'transporter' that mediates the transport of mainly organic anions across the cell membrane therefore, oatps are present in the lipid bilayer of the cell membrane, acting as the cell's gatekeepers. Organic anion transporting polypeptides (oatps) are a family of membrane uptake transporters that play important roles in absorption, distribution, metabolism and excretion of a wide range of endogenous and exogenous compounds oatp members, such as oatp1a2, 1b1 and 1b3, were found to transport numerous anticancer agents for this reason, these uptake transporters have been proposed to serve. Differential interaction of dicarboxylates with human sodium-dicarboxylate cotransporter 3 and organic anion transporters 1 and 3 marcel kaufhold,1 katharina schulz,1 davorka breljak,2 shivangi gupta,1 maja henjakovic,1 wolfgang krick,1 yohannes hagos,1 ivan sabolic,2 birgitta c burckhardt,1 and gerhard burckhardt1 1abteilung vegetative physiologie und pathophysiologie, universitätsmedizin.
The organic anion transporter 1 (oat1) also known as solute carrier family 22 member 6 (slc22a6) is a protein that in humans is encoded by the slc22a6 gene    it is a member of the organic anion transporter (oat) family of proteins. The iuphar/bps guide to pharmacology organic anion transporter 4 - organic anion transporters (oats) detailed annotation on the structure, function, physiology, pharmacology and clinical relevance of drug targets endou h (2002) interaction of human organic anion transporters with various cephalosporin antibiotics eur j. Competitive inhibition of human organic anion transporters 1 (slc22a6) and 3 (slc22a8) by major components of the medicinal systmeic level evaluation of organic anion transporters-mediated drug-drug interaction potency in salvia mitiorrhiza (danshen) preparations: focusing on. 7 li wang, douglas h sweet, interaction of natural dietary and herbal anionic compounds and flavonoids with human organic anion transporters 1 (slc22a6), 3 (slc22a8), and 4 (slc22a11), evidence-based complementary and alternative medicine, 2013, 2013, 1crossref.
Abstract1 human solute carrier transporters (slcs) are important membrane proteins mediate the cellular transport of many endogenous and exogenous substances organic anion/cation transporters (oats/octs) and organic anion transporting polypeptides (oatps) are essential slcs involved in drug influx drug–drug/herb interactions through competing for specific slcs often lead to unsatisfied. Abstract human organic anion transporter 4 (hoat4) belongs to a superfamily of organic ion transporters that play critical roles in the body disposition of clinically important drugs, including anti-hiv therapeutics, antitumor drugs, antibiotics, antihypertensives, and anti-inflammatories. To elucidate the entry pathway for mycotoxins into cells, we have investigated the interactions of human and rat organic anion transporters (hoats/roats) and human organic cation transporters.
Fig 1 tissue localization of selected human organic anion transporter proteins and their mechanism of action transporters located on the membrane domains of kidney proximal tubules, hepatocytes, choroid plexus epithelial cells, and placenta trophoblast cells are presented. Simultaneous administration of torasemide and probenecid lowered the diuretic effect and reduced torasemide clearance, suggesting organic anion transporters (oat) to be involved in renal secretion, because probenecid is the classical inhibitor of oat 3,4 the aim of this study was to elucidate the interaction of torasemide and its metabolites. Hsiang b, zhu y, wang z, wu y, sasseville v, yang wp, kirchgessner tg: a novel human hepatic organic anion transporting polypeptide (oatp2): identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-coa reductase inhibitor transporters. Background herb-drug interactions (hdis) resulting from concomitant use of herbal products with clinical drugs may cause adverse reactions organic anion transporter 1 (oat1) and 3 (oat3) are highly expressed in the kidney and play a key role in the renal elimination of substrate drugs. Inhibition of human organic anion transporter 3 mediated pravastatin transport by gemfibrozil and the metabolites in humans the inhibition of hoat3-mediated pravastatin transport by gemfibrozil and its metabolites would lead to a decrease in the renal clearance of pravastatin in clinical settings interactions of human- and rat-organic.
Interaction of human organic anion transporters
Abstract: human organic anion transporter 4 (hoat4) belongs to a family of organic anion transporters which play critical roles in the body disposition of clinically important drugs hoat4 is expressed in the kidney and placenta. Abstract: the hepatic organic anion transporting polypeptides (oatps) influence the pharmacokinetics of several drug classes and are involved in many clinical drug–drug interactions predicting potential interactions with oatps is, therefore, of value. The iuphar/bps guide to pharmacology organic anion transporter 3 - organic anion transporters (oats) detailed annotation on the structure, function, physiology, pharmacology and clinical relevance of drug targets endou h (2002) interaction of human organic anion transporters with various cephalosporin antibiotics eur j. Cells stably expressing human organic anion transporters ho jung shin, choong hee lee, su-jin park, jae-gook shin, and im-sook song department of pharmacology and pharmacogenomics research center, inje university college of medicine, busan 614.
Abstract studies of the organic anion transporters (oats) have focused mainly on their interactions with organic anionic substrates however, as suggested when oat1 was originally identified as nkt (lopez-nieto, c e. Interaction of natural dietary and herbal anionic compounds and flavonoids with human organic anion transporters 1 (slc22a6), 3 (slc22a8), and 4 (slc22a11) liwanganddouglashsweet departmentofpharmaceutics,virginiacommonwealthuniversity,410n12thstreet,richmond,va23298,usa. Recent investigations involving intact rabbit renal proximal tubules indicated that organic anion transporter 3 (oat3) may be involved in the transport of 2,3-dimercapto-1-propanesulfonic acid (dmps) therefore, we evaluated the interaction of oat3 with dmps to determine the effect of oat3 on basolateral dmps uptake we used stably transfected hek293 cells expressing human and rabbit orthologs.
Phylogentically, organic anion transporter (oat)1 and oat3 are closely related, whereas oat2 is more distant experiments with human embryonic kidney-293 cells stably transfected with human oat1, oat2, or oat3 were performed to compare selected transport properties. The organic anion transporters (oats) belong to the solute carrier family (slc) 22a with 12 transmembrane domains and are mainly expressed in the apical or basolateral membrane of the renal proximal tubules, the site of active drug secretion.